Jaseena Elikottil, MBBS 2 , Pankaj Gupta, MD 2 , and Kalpna Gupta, PhD 1 1 Division of
Hematology, Oncology and Transplantation and the Vascular Biology Center, University of
2 Department of Medicine, Minneapolis VA Medical Center


Historically and anecdotally cannabinoids have been used as analgesic agents. In recent years,
there has been an escalating interest in developing cannabis-derived medications to treat severe
pain. This review provides an overview of the history of cannabis use in medicine, cannabinoid
signaling pathways, and current data from preclinical as well as clinical studies on using
cannabinoids as potential analgesic agents. Clinical and experimental studies show that cannabis derived
compounds act as anti-emetic, appetite modulating and analgesic agents. However, the
efficacy of individual products is variable and dependent upon the route of administration. Since
opioids are the only therapy for severe pain, analgesic ability of cannabinoids may provide a
much-needed alternative to opioids. Moreover, cannabinoids act synergistically with opioids and
act as opioid sparing agents, allowing lower doses and fewer side effects from chronic opioid
therapy. Thus, rational use of cannabis based medications deserves serious consideration to
alleviate the suffering of patients due to severe pain.

Estudio completo: aquí